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Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides.

Abstract:

Our previous studies have identified a role for annexin 1 (ANXA1), a protein produced by the pituitary folliculostellate cells, as a paracrine/juxtacrine mediator of the acute regulatory effects of glucocorticoids on the release of adrenocorticotropic hormone and other pituitary hormones. In the present study, we focused on the secretion of thyroid stimulating hormone (TSH) and luteinizing hormone (LH) and used a battery of ANXA1-derived peptides to identify the key domains in the ANXA1 molec...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Morris, JF More by this author
Flower, RJ More by this author
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Journal:
Journal of neuroendocrinology
Volume:
15
Issue:
10
Pages:
946-957
Publication date:
2003-10-05
DOI:
EISSN:
1365-2826
ISSN:
0953-8194
URN:
uuid:a0c4e8fc-8d42-4802-89e8-75a1e196c128
Source identifiers:
114574
Local pid:
pubs:114574

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