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Journal article

DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts.

Abstract:

PURPOSE: This study uses a radiation chemistry approach to determine if DNA is an important target for radiation-induced apoptosis of myc (MR4) and myc plus ras (3.7) transfected rat embryo fibroblast cell lines. MATERIALS AND METHODS: The radiation protection efficiency of four thiols was compared with net molecular charge ranging from -1 to +2: mercaptopropionic acid (Z= -1), mercaptoethanol (Z=0), cysteamine (Z= +1), N(2-mercaptoethyl)-1,3-diaminopropane (Z= +2). Protection factors were de...

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Publication status:
Published

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Publisher copy:
10.1080/095530000138682

Authors


Bernhard, EJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Krisch, RE More by this author
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Journal:
International journal of radiation biology
Volume:
76
Issue:
3
Pages:
343-354
Publication date:
2000-03-05
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
URN:
uuid:a0c3bc3c-82b7-4f75-a70d-1f8c6bbe61ab
Source identifiers:
118170
Local pid:
pubs:118170

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