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Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

Abstract:

The microbiota confers colonization resistance, which blocks Salmonella gut colonization1. As diet affects microbiota composition, we studied whether food composition shifts enhance susceptibility to infection. Shifting mice to diets with reduced fibre or elevated fat content for 24 h boosted Salmonella Typhimurium or Escherichia coli gut colonization and plasmid transfer. Here, we studied the effect of dietary fat. Colonization resistance was restored within 48 h of return to maintenance die...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41564-019-0568-5

Authors


Publisher:
Nature Research Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
4
Pages:
2164–2174
Publication date:
2019-10-07
Acceptance date:
2019-08-23
DOI:
EISSN:
2058-5276
Language:
English
Keywords:
Pubs id:
pubs:1061252
UUID:
uuid:a0c29287-802f-4368-b9fd-50a22f6f8d8d
Local pid:
pubs:1061252
Source identifiers:
1061252
Deposit date:
2019-10-08

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