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Journal article

Ty virus-like particles, DNA vaccines and Modified Vaccinia Virus Ankara; comparisons and combinations.

Abstract:

Three types of vaccine, all expressing the same antigen from Plasmodium berghei, or a CD8+ T cell epitope from that antigen, were compared for their ability to induce CD8+ T cell responses in mice. Higher levels of lysis and numbers of IFN-gamma secreting T cells were primed with Ty virus-like particles and Modified Vaccinia Virus Ankara (MVA) than with DNA vaccines, but none of the vaccines were able to protect immunised mice from infectious challenge even after repeated doses. However, when...

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Publication status:
Published

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Publisher copy:
10.1515/bc.1999.041

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Biological chemistry
Volume:
380
Issue:
3
Pages:
299-303
Publication date:
1999-03-05
DOI:
EISSN:
1437-4315
ISSN:
1431-6730
URN:
uuid:a0b8968a-3871-462e-a299-be81d8d4f4db
Source identifiers:
31471
Local pid:
pubs:31471

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