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Time-dependent, HIV-Tat-induced perturbation of human neurons in vitro: towards a model for the molecular pathology of HIV-associated neurocognitive disorders

Abstract:

A significant proportion of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioral dysfunction that characterizes HIV-associated neurocognitive disorders (HAND). While the molecular etiology of HAND remains largely uncharacterized, HIV transactivator of transcription (HIV-Tat) is thought to be an important etiological cause. Here we have used mass spectrometry (MS)-based discovery proteomics to identify the quantitative, cell-wide ch...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fnmol.2017.00163

Authors


Gurwitz, KT More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
Balliol College
ORCID:
0000-0003-3107-7871
Murugan, BD More by this author
Garnett, S More by this author
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South African Medical Research Council More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Molecular Neuroscience Journal website
Volume:
10
Pages:
Article: 163
Publication date:
2017-05-29
Acceptance date:
2017-05-11
DOI:
ISSN:
1662-5099
Pubs id:
pubs:929597
URN:
uri:a0b71947-54da-4134-b90a-220a796de81b
UUID:
uuid:a0b71947-54da-4134-b90a-220a796de81b
Local pid:
pubs:929597

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