A comparison of the effects of human and ovine corticotropin-releasing hormone on the pituitary-adrenal axis.

Journal article

To compare the clinical efficacy of ovine and human sequence corticotropin-releasing hormone (CRH), we examined the effects of both peptides on ACTH and cortisol secretion in normal human volunteers, obese subjects, and patients with pituitary-dependent (Cushing's disease) and adrenal-dependent Cushing's syndrome. All subjects in each group were studied twice in random order. One hundred micrograms of CRH were administered as an iv bolus through an in-dwelling forearm cannula at 0930 h, and t...

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Authors: Trainer, P; Faria, M; Newell-Price, J; Browne, P; Kopelman, P

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 80
• Issue: 2
• Pages: 412-417
• Publication date: 1995-02-01
• DOI: 10.1210/jc.80.2.412
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Humans; Animals; Middle Aged; Adult; Obesity; Male; Adrenocorticotropic Hormone; Pituitary-Adrenal System; Reference Values; Aged; Sheep; Cushing Syndrome; Corticotropin-Releasing Hormone; Female; Hydrocortisone