Journal article
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
- Abstract:
-
Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfamily: DYRK1A with an ATP-mimetic inhibitor and consensus peptide, and DYRK2 including NAPA and DH (DYRK homology) box regions. The current activation model suggests that DYRKs are Ser/Thr kinases th...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.str.2013.03.012
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Authors
Bibliographic Details
- Journal:
- Structure (London, England : 1993)
- Volume:
- 21
- Issue:
- 6
- Pages:
- 986-996
- Publication date:
- 2013-06-01
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Source identifiers:
-
401241
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:401241
- UUID:
-
uuid:a0b14ad4-73d5-4078-b6b8-7fcc3ee6bba4
- Local pid:
- pubs:401241
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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