Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

Johnson, V; Lipton, LR; Cummings, C; Eftekhar Sadat, AT; Izatt, L; Hodgson, SV; Talbot, IC; Thomas, HJ; Silver, AJ; Tomlinson, IP

Abstract:

OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). METHODS: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), and expression of beta-catenin and p53) were examined in four series of CRC patients with proven or probable hereditary disease: hereditary non-polyposis colon cancer (HNPCC); MYH associated polypos...

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APA Style

Johnson, V., Lipton, L. R., Cummings, C., Eftekhar Sadat, A. T., Izatt, L., Hodgson, S. V., Talbot, I. C., Thomas, H. J., Silver, A. J., & Tomlinson, I. P. (2005). Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families. Journal of Medical Genetics, 42(10), 756–762.

MLA Style

Johnson, V., et al. “Analysis of Somatic Molecular Changes, Clinicopathological Features, Family History, and Germline Mutations in Colorectal Cancer Families: Evidence for Efficient Diagnosis of HNPCC and for the Existence of Distinct Groups of Non-HNPCC Families.” Journal of Medical Genetics, vol. 42, no. 10, Journal of medical genetics, 2005, pp. 756–62.

Chicago Style

Johnson, V, LR Lipton, C Cummings, AT Eftekhar Sadat, L Izatt, SV Hodgson, IC Talbot, HJ Thomas, AJ Silver, and IP Tomlinson. 2005. “Analysis of Somatic Molecular Changes, Clinicopathological Features, Family History, and Germline Mutations in Colorectal Cancer Families: Evidence for Efficient Diagnosis of HNPCC and for the Existence of Distinct Groups of Non-HNPCC Families.” Journal of Medical Genetics 42 (10): 756–62.
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