Journal article
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
- Abstract:
-
OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). METHODS: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), and expression of beta-catenin and p53) were examined in four series of CRC patients with proven or probable hereditary disease: hereditary non-polyposis colon cancer (HNPCC); MYH associated polypos...
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Bibliographic Details
- Journal:
- Journal of medical genetics
- Volume:
- 42
- Issue:
- 10
- Pages:
- 756-762
- Publication date:
- 2005-10-01
- DOI:
- EISSN:
-
1468-6244
- ISSN:
-
0022-2593
- Source identifiers:
-
72235
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72235
- UUID:
-
uuid:a0a7d933-f27d-4941-8776-ca1567624a29
- Local pid:
- pubs:72235
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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