Journal article icon

Journal article

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

Abstract:

OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). METHODS: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), and expression of beta-catenin and p53) were examined in four series of CRC patients with proven or probable hereditary disease: hereditary non-polyposis colon cancer (HNPCC); MYH associated polypos...

Expand abstract

Actions


Access Document


Publisher copy:
10.1136/jmg.2005.031245

Authors


Johnson, V More by this author
Lipton, LR More by this author
Cummings, C More by this author
Eftekhar Sadat, AT More by this author
Expand authors...
Journal:
Journal of medical genetics
Volume:
42
Issue:
10
Pages:
756-762
Publication date:
2005-10-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:a0a7d933-f27d-4941-8776-ca1567624a29
Source identifiers:
72235
Local pid:
pubs:72235

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP