Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis.

Conference item

Presence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold), relative to their level in peripheral blood (P=.014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ...

Expand abstract

Authors: Wilkinson, K; Wilkinson, R; Pathan, A; Ewer, K; Prakash, M

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 40
• Issue: 1
• Pages: 184-187
• Publication date: 2005-01-01
• Event title: Symposium on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era
• DOI: 10.1086/426139
• EISSN: 1537-6591
• ISSN: 1058-4838
• Keywords: Interferon-gamma; Male; T-Lymphocyte Subsets; Adult; Antigens, Bacterial; Antigens, Differentiation, T-Lymphocyte; Pleural Effusion; Lymphocyte Activation; Tuberculosis, Pleural; Female; Humans; Bacterial Proteins