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Journal article

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

Abstract:

E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins, the newest member of the family, DP-4, downregulates E2F activity. In this study we report an unexpected role for DP-4 in regulating E2F-1 activity during the DNA damage response. Specifically, DP-4 is induced in DNA-damaged cells, upon which it...

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Publication status:
Published

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Publisher copy:
10.1038/cdd.2010.70

Authors


Coutts, AS More by this author
La Thangue, NB More by this author
Journal:
Cell death and differentiation
Volume:
18
Issue:
1
Pages:
122-132
Publication date:
2011-01-05
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
URN:
uuid:a09ecf81-9b71-4b9e-b067-f354c4735a7f
Source identifiers:
248165
Local pid:
pubs:248165

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