E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

Journal article

E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins, the newest member of the family, DP-4, downregulates E2F activity. In this study we report an unexpected role for DP-4 in regulating E2F-1 activity during the DNA damage response. Specifically, DP-4 is induced in DNA-damaged cells, upon which it...

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Authors: Ingram, L; Munro, S; Coutts, A; La Thangue, N

• Publication status: Published
• Journal: Cell death and differentiation
• Volume: 18
• Issue: 1
• Pages: 122-132
• Publication date: 2011-01-01
• DOI: 10.1038/cdd.2010.70
• EISSN: 1476-5403
• ISSN: 1350-9047
• Language: English
• Keywords: DNA Damage; Protein Binding; RNA Interference; Protein Structure, Tertiary; E2F1 Transcription Factor; Mutation; Transcription Factor DP1; RNA, Small Interfering; DNA; Molecular Sequence Data; DNA Repair; Amino Acid Sequence; Protein Subunits; Humans; Cell Line, Tumor