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The expanding role of co-trimoxazole in developing countries.

Abstract:

Co-trimoxazole is an inexpensive, broad-spectrum antimicrobial drug that is widely used in developing countries. Before antiretroviral therapy (ART) scale-up, co-trimoxazole prophylaxis reduced morbidity and mortality in adults and children with HIV by preventing bacterial infections, diarrhoea, malaria, and Pneumocystis jirovecii pneumonia, despite high levels of microbial resistance. Co-trimoxazole prophylaxis reduces early mortality by 58% (95% CI 39-71) in adults starting ART. Co-trimoxaz...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Lancet. Infectious diseases
Publication date:
2014-11-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Source identifiers:
492070
Language:
English
Pubs id:
pubs:492070
UUID:
uuid:a09e4d25-e8b8-44ab-9599-22967aafe57e
Local pid:
pubs:492070
Deposit date:
2014-12-15

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