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Safety of oral bisphosphonates in moderate-to-severe chronic kidney disease: a binational cohort analysis

Abstract:

Bisphosphonates are the first-line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution in chronic kidney disease (CKD) patients, primarily because of a lack of information about their safety and effectiveness. We aimed to investigate the safety of oral bisphosphonates in patients with moderate to severe CKD, using primary-care electronic records from two cohorts, CPRD GOLD (1997–2016) and SIDIAP (2007–2015) in the UK an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/jbmr.4235

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-0940-9211
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-4192-7908
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0001-7908-1912
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Publisher:
Wiley Publisher's website
Journal:
Journal of Bone and Mineral Research Journal website
Volume:
36
Issue:
5
Pages:
820-832
Publication date:
2021-02-08
Acceptance date:
2020-12-11
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Language:
English
Keywords:
Pubs id:
1149640
Local pid:
pubs:1149640
Deposit date:
2020-12-14

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