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Chromosome replication dynamics in the archaeon Sulfolobus acidocaldarius.

Abstract:

The "baby machine" provides a means of generating synchronized cultures of minimally perturbed cells. We describe the use of this technique to establish the key cell-cycle parameters of hyperthermophilic archaea of the genus Sulfolobus. The 3 DNA replication origins of Sulfolobus acidocaldarius were mapped by 2D gel analysis to near 0 (oriC2), 579 (oriC1), and 1,197 kb (oriC3) on the 2,226-kb circular genome, and we present a direct demonstration of their activity within the first few minutes...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0806414105

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
43
Pages:
16737-16742
Publication date:
2008-10-15
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a0959f1e-f774-4f4d-9349-a6240d0afd47
Source identifiers:
3517
Local pid:
pubs:3517

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