Journal article icon

Journal article

The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance.

Abstract:

DM43 is a circulating dimeric antitoxin isolated from Didelphis aurita, a South American marsupial naturally immune to snake envenomation. This endogenous inhibitor binds non-covalently to jararhagin, the main hemorrhagic metalloproteinase from Bothrops jararaca snake venom, and efficiently neutralizes its toxicity. The aim of this study was to apply mass spectrometry (MS) and surface plasmon resonance (SPR) to improve the molecular characterization of this heterocomplex. The stoichiometry of...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/jms.2990

Authors


Expand authors...
Journal:
Journal of mass spectrometry : JMS
Volume:
47
Issue:
5
Pages:
567-573
Publication date:
2012-05-01
DOI:
EISSN:
1096-9888
ISSN:
1076-5174
Source identifiers:
333682
Language:
English
Keywords:
Pubs id:
pubs:333682
UUID:
uuid:a08f1c46-7239-4d77-a029-2b85f3db0a92
Local pid:
pubs:333682
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP