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The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance.

Abstract:

DM43 is a circulating dimeric antitoxin isolated from Didelphis aurita, a South American marsupial naturally immune to snake envenomation. This endogenous inhibitor binds non-covalently to jararhagin, the main hemorrhagic metalloproteinase from Bothrops jararaca snake venom, and efficiently neutralizes its toxicity. The aim of this study was to apply mass spectrometry (MS) and surface plasmon resonance (SPR) to improve the molecular characterization of this heterocomplex. The stoichiometry of...

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Publication status:
Published

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Publisher copy:
10.1002/jms.2990

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Journal:
Journal of mass spectrometry : JMS
Volume:
47
Issue:
5
Pages:
567-573
Publication date:
2012-05-05
DOI:
EISSN:
1096-9888
ISSN:
1076-5174
URN:
uuid:a08f1c46-7239-4d77-a029-2b85f3db0a92
Source identifiers:
333682
Local pid:
pubs:333682

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