The fetal origins of osteoporotic fracture.

Journal article

Undemutrition and other adverse influences arising in fetal life or immediately after birth have a permanent effect on body structure, physiology, and metabolism. The specific effects of undernutrition depend on the time and development at which it occurs; rapidly growing fetuses and neonates are more vulnerable. Its effects include altered gene expression, reduced cell numbers, imbalance between cell types, altered organ structure, and changes in the pattern of hormonal release and tissue se...

Expand abstract

Authors: Cooper, C; Javaid, M; Taylor, P; Walker-Bone, K; Dennison, E

• Publication status: Published
• Journal: Calcified tissue international
• Volume: 70
• Issue: 5
• Pages: 391-394
• Publication date: 2002-05-01
• DOI: 10.1007/s00223-001-0044-z
• EISSN: 1432-0827
• ISSN: 0171-967X
• Language: English
• Keywords: Models, Animal; Humans; Fetus; Bone Density; Fractures, Bone; Child; Chronic Disease; Maternal Nutritional Physiological Phenomena; Osteoporosis; Animals