Thesis
Total synthesis and stereochemical reassignment of dehydromicrosclerodermin B and microsclerodermin J
- Abstract:
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This thesis describes research towards the total synthesis of two marine natural products, dehydromicrosclerodermin B and microsclerodermin J. The synthesis of the most complex subunit of these peptides, AMMTD, was accomplished in a longest linear sequence of 21 steps starting from (S)-Roche ester. Preliminary results conducted by other group members were improved; the key cuprate displacement reaction and the final steps of the synthetic sequence were developed. Subsequently, AMMTD-GABOB ...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:a0894f3b-0209-4feb-957e-9c4b0bdb60a8
- Deposit date:
- 2017-02-26
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Terms of use
- Copyright holder:
- Melikhova, E
- Copyright date:
- 2016
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