Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

Journal article

Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence is required for robust drug responses. Both in primary and acquired resistance, MITF levels inversely correlate with the expression of several activated receptor tyrosine kinases, most frequently AXL. The MITF-low/...

Expand abstract

Authors: Müller, J; Krijgsman, O; Tsoi, J; Robert, L; Hugo, W

• Journal: Nature communications
• Volume: 5
• Pages: 5712
• Publication date: 2014-01-01
• DOI: 10.1038/ncomms6712
• EISSN: 2041-1723
• Language: English