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Association of the TSHR gene with Graves' disease: The first disease specific locus

Abstract:

The development of autoimmune thyroid disease (AITD) is associated with autoantibodies directed against the thyroid stimulating hormone receptor (TSHR). Previous studies have failed to demonstrate a consistent association between the TSHR and AITD, or any of its sub-phenotypes. In the present study, we analysed the linkage disequilibrium (LD) structure encompassing the TSHR, to identify LD 'blocks' and SNPs, which capture the majority of intra-block haplotype diversity. The haplotype tagging ...

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Publisher copy:
10.1038/sj.ejhg.5201485

Authors


Dechairo, BM More by this author
Zabaneh, D More by this author
Collins, J More by this author
Dawson, GJ More by this author
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Journal:
European Journal of Human Genetics
Volume:
13
Issue:
11
Pages:
1223-1230
Publication date:
2005-11-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:a0827f75-41c5-47ab-94b0-2c858ddaa64f
Source identifiers:
176333
Local pid:
pubs:176333
Language:
English
Keywords:

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