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Microevolutionary analysis of Clostridium difficile genomes to investigate transmission

Abstract:

Background: The control of Clostridium difficile infection is a major international healthcare priority, hindered by a limited understanding of transmission epidemiology for these bacteria. However, transmission studies of bacterial pathogens are rapidly being transformed by the advent of next generation sequencing.
Results: Here we sequence whole C. difficile genomes from 486 cases arising over four years in Oxfordshire. We show that we can...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/gb-2012-13-12-r118

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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087646/Z/08/Z/Wellcome Trust More from this funder
090532/Wellcome Trust More from this funder
090532/Z/09/Z/Wellcome Trust More from this funder
DRF-2010-03-40/Department of Health More from this funder
G0600719B/Medical Research Council More from this funder
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Publisher:
BioMed Central Publisher's website
Journal:
Genome Biology Journal website
Volume:
13
Issue:
12
Pages:
R118
Publication date:
2012-12-21
Acceptance date:
2012-12-21
DOI:
EISSN:
1465-6906
ISSN:
1474-760X
Pubs id:
pubs:369865
URN:
uri:a0826485-207e-4021-a39b-6f2c4e25bb15
UUID:
uuid:a0826485-207e-4021-a39b-6f2c4e25bb15
Local pid:
pubs:369865

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