- Abstract:
- Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.
- Publication status:
- Published
- Publisher copy:
- 10.1080/15257770701501534
-
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- Journal:
- Nucleosides, nucleotides and nucleic acids
- Volume:
- 26
- Issue:
- 6-7
- Pages:
- 785-794
- Publication date:
- 2007-01-01
- DOI:
- EISSN:
-
1532-2335
- ISSN:
-
1525-7770
- URN:
-
uuid:a07c1229-33a4-431d-ad72-555d250f0f0f
- Source identifiers:
-
400018
- Local pid:
- pubs:400018
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer.
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