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Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer.

Abstract:
Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.
Publication status:
Published

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Publisher copy:
10.1080/15257770701501534

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nucleosides, nucleotides and nucleic acids
Volume:
26
Issue:
6-7
Pages:
785-794
Publication date:
2007-01-01
DOI:
EISSN:
1532-2335
ISSN:
1525-7770
Source identifiers:
400018
Language:
English
Keywords:
Pubs id:
pubs:400018
UUID:
uuid:a07c1229-33a4-431d-ad72-555d250f0f0f
Local pid:
pubs:400018
Deposit date:
2013-11-16

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