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Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer.

Abstract:
Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.
Publication status:
Published

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Publisher copy:
10.1080/15257770701501534

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Nucleosides, nucleotides and nucleic acids
Volume:
26
Issue:
6-7
Pages:
785-794
Publication date:
2007-01-01
DOI:
EISSN:
1532-2335
ISSN:
1525-7770
URN:
uuid:a07c1229-33a4-431d-ad72-555d250f0f0f
Source identifiers:
400018
Local pid:
pubs:400018

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