Thesis icon

Thesis

Investigating resistance of glioblastoma multiforme to radiotherapy and chemotherapy

Abstract:

Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumour. Despite treatment with surgery, radiotherapy and temozolomide (TMZ) chemotherapy, patient survival remains poor, suggesting that GBM cells evade and resist these therapies. The insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase that signals towards cellular survival, proliferation and motility. Previous work from our laboratory showed that IGF-1R inhibition sensitises other tumou...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Department:
Somerville College, Oxford
Role:
Author

Contributors

Department:
Department of Oncology
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP