- Abstract:
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Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumour. Despite treatment with surgery, radiotherapy and temozolomide (TMZ) chemotherapy, patient survival remains poor, suggesting that GBM cells evade and resist these therapies. The insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase that signals towards cellular survival, proliferation and motility. Previous work from our laboratory showed that IGF-1R inhibition sensitises other tumou...
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- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
- English
- Keywords:
- Subjects:
- Copyright date:
- 2016
Thesis
Investigating resistance of glioblastoma multiforme to radiotherapy and chemotherapy
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