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Subtype-specific actions of β-amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (α7, α4β2, α3β4) expressed in Xenopus laevis oocytes

Abstract:

1 Two-electrode voltage-clamp electrophysiology has been used to study the actions of two amyloid peptides (Aβ 1-42, Aβ 1-40) on α7, α4β2 and α3β4 recombinant human neuronal nicotinic acetylcholine receptors (nicotinic AChRs), heterologously expressed in Xenopus laevis oocytes. 2 The application of Aβ 1-42 or Aβ 1-40 (1 pM-100 nM) for 5 s does not directly activate expressed human α7, α4β2 or α3β4 nicotinic AChRs. 3 Aβ 1-42 and Aβ 1-40 are antagonists of α7 nicotinic AChRs. For example, 10 nM...

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Publisher copy:
10.1038/sj.bjp.0706403

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Journal:
British Journal of Pharmacology
Volume:
146
Issue:
7
Pages:
964-971
Publication date:
2005-12-01
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Source identifiers:
115461
Language:
English
Keywords:
Pubs id:
pubs:115461
UUID:
uuid:a06f0358-e24f-46df-a5ba-78aa8432e2ce
Local pid:
pubs:115461
Deposit date:
2013-11-17

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