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Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis.

Abstract:

Trypanosoma brucei has a single nucleus and a single kinetoplast (the mitochondrial genome). Each of these organelles has a distinct S phase, which is followed by a segregation period, prior to cell division. The segregation of the two genomes takes place in a specific temporal order by interaction with microtubule-based structures, the spindle for nuclear DNA and the flagellum basal bodies for the kinetoplast DNA. We used rhizoxin, the anti-microtubule agent and polymerisation inhibitor, or ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
112 ( Pt 24)
Issue:
24
Pages:
4641-4650
Publication date:
1999-12-01
EISSN:
1477-9137
ISSN:
0021-9533
Source identifiers:
28972
Language:
English
Keywords:
Pubs id:
pubs:28972
UUID:
uuid:a0617e60-5ced-4802-9685-273934f64aba
Local pid:
pubs:28972
Deposit date:
2012-12-19

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