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Journal article

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.

Abstract:

The exogenous administration of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), has been shown to reduce left ventricular hypertrophy, fibrosis, and cardiac dysfunction in mice with pre-established heart disease induced by pressure-overload. In this setting, BH4 re-coupled endothelial NOS (eNOS), with subsequent reduction of NOS-dependent oxidative stress and reversal of maladaptive remodeling. However, recent studies suggest the effective BH4 dosing may be na...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2011.05.017

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Journal:
Journal of molecular and cellular cardiology More from this journal
Volume:
51
Issue:
4
Pages:
564-569
Publication date:
2011-10-01
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Language:
English
Keywords:
Pubs id:
pubs:151201
UUID:
uuid:a05b27d0-95fb-4050-89bc-2e7ff08059fe
Local pid:
pubs:151201
Source identifiers:
151201
Deposit date:
2012-12-19

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