Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations.

Journal article

We examine the rules governing Ti beta variable (V) gene segment usage in the formation of T cell antigen-MHC receptors in diverse regulatory and effector T lymphoid subpopulations. To this end, a single Ti beta V gene family and its products were analyzed. A monoclonal antibody, termed anti-Ti3A, which was shown to be reactive with an epitope encoded by members of the REX cell line Ti beta V gene family, and which was expressed on 2% of human T lymphocytes was used in selection of clones fro...

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Authors: Acuto, O; Campen, T; Royer, H; Hussey, R; Poole, C

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 161
• Issue: 6
• Pages: 1326-1343
• Publication date: 1985-06-01
• DOI: 10.1084/jem.161.6.1326
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Epitopes; Receptors, Antigen, T-Cell; DNA; Molecular Conformation; Genes; Clone Cells; T-Lymphocytes; Humans; Antibodies, Monoclonal