A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer.

Journal article

PURPOSE: Tumor hypoxia is associated with a poor prognosis, hypoxia modification improves outcome, and hypoxic status predicts benefit from treatment. Yet, there is no universal measure of clinical hypoxia. The aim of this study was to investigate whether a 26-gene hypoxia signature predicted benefit from hypoxia-modifying treatment in both cancer types. EXPERIMENTAL DESIGN: Samples were available from 157 T2-T4 laryngeal cancer and 185 T1-T4a bladder cancer patients enrolled on the accelerat...

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Authors: Eustace, A; Mani, N; Span, P; Irlam, J; Taylor, J

• Publication status: Published
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
• Volume: 19
• Issue: 17
• Pages: 4879-4888
• Publication date: 2013-09-01
• DOI: 10.1158/1078-0432.ccr-13-0542
• EISSN: 1557-3265
• ISSN: 1078-0432
• Language: English
• Keywords: Radiation-Sensitizing Agents; Cell Hypoxia; Gene Expression Regulation, Neoplastic; Niacinamide; Laryngeal Neoplasms; Oxygen; Carbon Dioxide; Female; Male; Humans; Urinary Bladder Neoplasms