Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.

Journal article

Macrophage class A scavenger receptor types I and II (SR-AI and II) mediate the uptake of oxidized LDL in atherosclerotic lesions. The recently described type III receptor (SR-AIII), which lacks amino acids encoded by exon 10 of the SR-A gene, is unable to mediate the uptake of ligands and acts as a dominant negative regulator in the trimeric SR-A molecule. To find out whether SR-AIII might play a role in the regulation of SR-A activity in the arterial wall, we studied its expression in norma...

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Authors: Hiltunen, T; Gough, P; Greaves, D; Gordon, S; Ylä-Herttuala, S

• Publication status: Published
• Journal: Atherosclerosis
• Volume: 154
• Issue: 2
• Pages: 415-419
• Publication date: 2001-02-01
• DOI: 10.1016/s0021-9150(00)00519-0
• EISSN: 1879-1484
• ISSN: 0021-9150
• Language: English
• Keywords: Cholesterol, Dietary; Scavenger Receptors, Class B; Receptors, Lipoprotein; Arteriosclerosis; Aorta; Animals; Receptors, Immunologic; Male; Tunica Intima; Aortic Diseases; Scavenger Receptors, Class A; Receptors, Scavenger; Membrane Proteins; RNA Splice Sites; Gene Expression; Rabbits; Cell Adhesion Molecules; Reverse Transcriptase Polymerase Chain Reaction; DNA Primers; RNA, Messenger