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Chromosomal location of human T-cell receptor gene Ti beta.

Abstract:
A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.
Publication status:
Published

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Publisher copy:
10.1126/science.6435246

Authors


Barker, PE More by this author
Ruddle, FH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Reinherz, EL More by this author
Journal:
Science (New York, N.Y.)
Volume:
226
Issue:
4672
Pages:
348-349
Publication date:
1984-10-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:a04563ee-df86-4827-a397-0d4c290af4fc
Source identifiers:
16927
Local pid:
pubs:16927

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