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Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma.

Abstract:

Clinical trials of agents targeting epidermal growth factor receptor (EGFR) in esophageal carcinoma (EC) have indicated a minority subgroup responsive to anti-EGFR therapies. Other investigations suggest increases in EGFR copy number are associated with poor prognosis in EC, but have used a variety of different techniques and tested numbers remain small. A validated assay for EGFR copy number in EC is needed, to allow investigation of EGFR copy number gain as a predictive biomarker for the an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13039-015-0181-0

Authors


Dahle-Smith, Å More by this author
Stevenson, D More by this author
Murray, GI More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
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Publisher:
BioMed Central Publisher's website
Journal:
Molecular cytogenetics Journal website
Volume:
8
Issue:
1
Pages:
78
Publication date:
2015
DOI:
EISSN:
1755-8166
ISSN:
1755-8166
URN:
uuid:a045039b-aa05-4b8e-8024-1e1e25fdf384
Source identifiers:
573108
Local pid:
pubs:573108

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