- Abstract:
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Genome-wide association studies have greatly improved our understanding of the contribution of common variants to the genetic architecture of complex traits. However, two major limitations have been highlighted. First, common variant associations typically do not identify the causal variant and/or the gene that it is exerting its effect on to influence a trait. Second, common variant associations usually consist of variants with small effects. As a consequence, it is more challenging to ha...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Funding agency for:
- Manuel Antonio Rivas Cruz
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:a042ca18-7b35-4a62-aef0-e3ba2e8795f7
- Local pid:
- ora:12195
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Manuel Antonio Rivas Cruz
- Copyright date:
- 2015
Thesis
Medical relevance and functional consequences of protein truncating variants
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+ The Clarendon Fund; Nuffield Department of Medicine
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