Thesis
Medical relevance and functional consequences of protein truncating variants
- Abstract:
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Genome-wide association studies have greatly improved our understanding of the contribution of common variants to the genetic architecture of complex traits. However, two major limitations have been highlighted. First, common variant associations typically do not identify the causal variant and/or the gene that it is exerting its effect on to influence a trait. Second, common variant associations usually consist of variants with small effects. As a consequence, it is more challenging to ha...
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Funding
+ The Clarendon Fund; Nuffield Department of Medicine
More from this funder
Funding agency for:
Rivas Cruz, M
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:a042ca18-7b35-4a62-aef0-e3ba2e8795f7
- Local pid:
- ora:12195
- Deposit date:
- 2015-09-02
Terms of use
- Copyright holder:
- Rivas Cruz, M
- Copyright date:
- 2015
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