Journal article
Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease.
- Abstract:
-
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant polymorphisms in the endothelial NO synthase (NOS-3) gene may contribute to the development of CHD. NOS-3 expression was analyzed in endothelial cells isolated from umbilical cords genotyped for the -...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/01.res.0000145359.47708.2f
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Authors
Bibliographic Details
- Journal:
- Circulation research
- Volume:
- 95
- Issue:
- 8
- Pages:
- 841-847
- Publication date:
- 2004-10-05
- DOI:
- EISSN:
-
1524-4571
- ISSN:
-
0009-7330
- URN:
-
uuid:a04222c4-c814-43f9-917d-f244ed3c4860
- Source identifiers:
-
104812
- Local pid:
- pubs:104812
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2004
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