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Journal article

Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease.

Abstract:

Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant polymorphisms in the endothelial NO synthase (NOS-3) gene may contribute to the development of CHD. NOS-3 expression was analyzed in endothelial cells isolated from umbilical cords genotyped for the -...

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Publication status:
Published

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Authors


Cattaruzza, M More by this author
Słodowski, W More by this author
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Journal:
Circulation research
Volume:
95
Issue:
8
Pages:
841-847
Publication date:
2004-10-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:a04222c4-c814-43f9-917d-f244ed3c4860
Source identifiers:
104812
Local pid:
pubs:104812

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