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Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Abstract:

Renal cell carcinoma (RCC) infiltrating lymphocytes (TILs) express killer cell immunoglobulinlike receptors (KIRs) that inhibit the antitumor CD8(+) T-cell lysis. In the present study, to better examine the functional consequences of KIR engagement on cytotoxic T lymphocyte (CTL)/tumor interaction, we have investigated the influence of KIR CD158a on early steps of T-cell activation. We show that coengagement of T-cell receptor (TCR) and CD158a by tumor cells inhibited tyrosine phosphorylation...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2002-02-0643

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Journal:
Blood
Volume:
100
Issue:
8
Pages:
2874-2881
Publication date:
2002-10-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:a04145a4-cfb7-49fb-b706-7382c4640bea
Source identifiers:
14654
Local pid:
pubs:14654

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