- Abstract:
-
Renal cell carcinoma (RCC) infiltrating lymphocytes (TILs) express killer cell immunoglobulinlike receptors (KIRs) that inhibit the antitumor CD8(+) T-cell lysis. In the present study, to better examine the functional consequences of KIR engagement on cytotoxic T lymphocyte (CTL)/tumor interaction, we have investigated the influence of KIR CD158a on early steps of T-cell activation. We show that coengagement of T-cell receptor (TCR) and CD158a by tumor cells inhibited tyrosine phosphorylation...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2002-02-0643
-
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- Journal:
- Blood
- Volume:
- 100
- Issue:
- 8
- Pages:
- 2874-2881
- Publication date:
- 2002-10-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:a04145a4-cfb7-49fb-b706-7382c4640bea
- Source identifiers:
-
14654
- Local pid:
- pubs:14654
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.
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