Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide.

Journal article

OBJECTIVE: Microparticles of iron oxide (MPIO) distort magnetic field creating marked contrast effects far exceeding their physical size. We hypothesized that antibody-conjugated MPIO would enable magnetic resonance imaging (MRI) of endothelial cell adhesion molecules in mouse atherosclerosis. METHODS AND RESULTS: MPIO (4.5 microm) were conjugated to monoclonal antibodies against vascular cell adhesion molecule-1 (VCAM-MPIO) or P-selectin (P-selectin-MPIO). In vitro, VCAM-MPIO bound, in dose-...

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Authors: McAteer, M; Schneider, J; Ali, Z; Warrick, N; Bursill, C

• Publication status: Published
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Volume: 28
• Issue: 1
• Pages: 77-83
• Publication date: 2008-01-01
• DOI: 10.1161/atvbaha.107.145466
• EISSN: 1524-4636
• ISSN: 1079-5642
• Language: English
• Keywords: Vascular Cell Adhesion Molecule-1; Mice, Knockout; Arteriosclerosis; Sensitivity and Specificity; Cell Adhesion; Ferric Compounds; Endothelium, Vascular; P-Selectin; Mice; Particle Size; Animals; Magnetic Resonance Imaging; Apolipoproteins E