Investigating circadian disruption in mouse models of neurological and metabolic disorders
Sleep and circadian rhythm disturbance has been widely observed in neurological disorders although the mechanistic basis for this association remains unknown. In order to understand this association further, a combination of rest/activity and molecular profiling was carried out on mouse models of Parkinson’s Disease (PD), Lysosomal Storage Disorders (LSDs) and schizophrenia.
Data from rest/activity behavioural screening of new BAC (Bacterial Artificial Chromosome) transgenic PD mode...Expand abstract
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- Oxford University, UK
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- Achilleas Livieratos
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- This thesis is not currently available in ORA.
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