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Thesis

Investigating circadian disruption in mouse models of neurological and metabolic disorders

Abstract:

Sleep and circadian rhythm disturbance has been widely observed in neurological disorders although the mechanistic basis for this association remains unknown. In order to understand this association further, a combination of rest/activity and molecular profiling was carried out on mouse models of Parkinson’s Disease (PD), Lysosomal Storage Disorders (LSDs) and schizophrenia.

Data from rest/activity behavioural screening of new BAC (Bacterial Artificial Chromosome) transgenic PD mode...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Anatomy and Genetics

Contributors

Role:
Supervisor
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Funding agency for:
Achilleas Livieratos
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a03f34d5-285d-464b-b676-21b493db7f56
Local pid:
ora:8840

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