Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses.

Journal article

Both human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) lead to chronic infection in a high percentage of persons, and an expanding epidemic of HIV-1-HCV coinfection has recently been identified. These individuals provide an opportunity for simultaneous assessment of immune responses to two viral infections associated with chronic plasma viremia. In this study we analyzed the breadth and magnitude of the CD8(+)- and CD4(+)-T-lymphocyte responses in 22 individuals infected...

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Authors: Lauer, G; Nguyen, T; Day, C; Robbins, G; Flynn, T

• Publication status: Published
• Journal: Journal of virology
• Volume: 76
• Issue: 6
• Pages: 2817-2826
• Publication date: 2002-03-01
• DOI: 10.1128/jvi.76.6.2817-2826.2002
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: CD8-Positive T-Lymphocytes; Viral Load; Hepacivirus; Adult; Male; HIV Infections; RNA, Viral; CD4-Positive T-Lymphocytes; Humans; Hepatitis C; Middle Aged; Female; HIV-1