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The role of RNA processing in the pathogenesis of motor neuron degeneration

Abstract:

Motor neurons are large, highly polarised cells with very long axons and a requirement for precise spatial and temporal gene expression. Neurodegenerative disorders characterised by selective motor neuron vulnerability include various forms of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). A rapid expansion in knowledge on the pathophysiology of motor neuron degeneration has occurred in recent years, largely through the identification of genes leading to familial forms...

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Publisher copy:
10.1017/S1462399410001523

Authors


Bäumer, D More by this author
Ansorge, O More by this author
Almeida, M More by this author
Journal:
Expert Reviews in Molecular Medicine
Volume:
12
Publication date:
2010-02-05
DOI:
ISSN:
1462-3994
URN:
uuid:a017eb1e-997c-477c-b108-58c8b73c95ad
Source identifiers:
341671
Local pid:
pubs:341671
Language:
English

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