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Genetics and the general physician: insights, applications and future challenges.

Abstract:

Scientific and technological advances in our understanding of the nature and consequences of human genetic variation are now allowing genetic determinants of susceptibility to common multifactorial diseases to be defined, as well as our individual response to therapy. I review how genome-wide association studies are robustly identifying new disease susceptibility loci, providing insights into disease pathogenesis and potential targets for drug therapy. Some of the remarkable advances being ma...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/qjmed/hcp115

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Molecular Medicine, WTC Human Genetics
Role:
Author
More from this funder
Funding agency for:
Knight, JC
Publisher:
Oxford University Press Publisher's website
Journal:
QJM : monthly journal of the Association of Physicians Journal website
Volume:
102
Issue:
11
Pages:
757-772
Publication date:
2009-11-05
DOI:
EISSN:
1460-2393
ISSN:
1460-2725
URN:
uuid:a00e5ad0-01dd-4283-b4c0-7bea50b47dc8
Source identifiers:
3001
Local pid:
pubs:3001

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