Journal article icon

Journal article

Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.

Abstract:

Adenovirus gene therapy for intraperitoneal (IP) cancer is limited in clinical trials by inefficient tumor cell transduction and development of peritoneal adhesions. We have shown previously that normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus "retargeting" through chosen receptors. To achieve tumor-selective infection, polymer-coated virus was retargeted using murine epidermal gro...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.mt.6300363

Authors


Morrison, J More by this author
Briggs, SS More by this author
Expand authors...
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
16
Issue:
2
Pages:
244-251
Publication date:
2008-02-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:a00c4057-097e-4ab9-af49-c100c8b5113f
Source identifiers:
178570
Local pid:
pubs:178570

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP