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Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

Abstract:

Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the varie...

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Publisher copy:
10.1007/s10853-014-8325-x

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Publisher:
Kluwer Academic Publishers
Journal:
Journal of Materials Science
Volume:
49
Issue:
17
Pages:
5809-5820
Publication date:
2014-01-01
DOI:
EISSN:
1573-4803
ISSN:
0022-2461
URN:
uuid:a00ba589-74f4-413c-a1d0-07d9d06b2d53
Source identifiers:
476791
Local pid:
pubs:476791
Language:
English

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