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Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.

Abstract:

The mode of binding of oligosaccharides to griffithsin, an antiviral lectin from the red alga Griffithsia sp., was investigated by a combination of X-ray crystallography, isothermal titration calorimetry, and molecular modeling. The structures of complexes of griffithsin with 1-->6alpha-mannobiose and with maltose were solved and refined at the resolution of 2.0 and 1.5 A, respectively. The thermodynamic parameters of binding of 1-->6alpha-mannobiose, maltose, and mannose to griffithsin...

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Publication status:
Published

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Publisher copy:
10.1002/prot.21336

Authors


Ziółkowska, NE More by this author
Shenoy, SR More by this author
O'Keefe, BR More by this author
McMahon, JB More by this author
Palmer, KE More by this author
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Journal:
Proteins
Volume:
67
Issue:
3
Pages:
661-670
Publication date:
2007-05-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:a00a3dfe-3bd4-41d5-beef-3204fcf827f0
Source identifiers:
100307
Local pid:
pubs:100307

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