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Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.

Abstract:

BACKGROUND: Alterations in coronary vasomotor tone may participate in the pathogenesis of acute myocardial infarction (AMI). Vascular ATP-sensitive K(+) (KATP) channels, formed by Kir6.x/SUR2B, are key regulators of coronary tone and mutations in cardiac (Kir6.2/SUR2A) KATP channels result in heart disease. Here we explore the pathophysiological mechanism of a rare mutation (V734I) found in exon 17 of the ABCC9 gene, estimated to cause a 6.4-fold higher risk of AMI before the age of 60. METHO...

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Publication status:
Published

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Journal:
International journal of cardiology
Volume:
168
Issue:
4
Pages:
3506-3513
Publication date:
2013-10-05
DOI:
EISSN:
1874-1754
ISSN:
0167-5273
URN:
uuid:9ff7fbad-c1e2-4d5b-bf9e-0acc270a87b4
Source identifiers:
406708
Local pid:
pubs:406708

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