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The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.

Abstract:

The transcription factor C/EBP alpha (CCAAT/enhancer binding protein alpha) is critical for granulopoiesis. Gene disruption in mice blocks early granulocyte differentiation and disruption of C/EBP alpha function has been implicated in human acute myeloid leukemia (AML), but no systematic structure-function analysis has been undertaken to identify the mechanisms involved in C/EBP alpha-mediated granulocyte differentiation. Here we demonstrate that loss of either of 2 key regions results in dis...

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Publisher copy:
10.1182/blood-2003-02-0479

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Journal:
Blood
Volume:
102
Issue:
9
Pages:
3163-3171
Publication date:
2003-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:9ff242d4-9019-4538-82f7-d33430735446
Source identifiers:
324039
Local pid:
pubs:324039

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