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Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17.

Abstract:

Coronary artery disease (CAD) is a leading cause of death world-wide, and most cases have a complex, multifactorial aetiology that includes a substantial heritable component. Identification of new genes involved in CAD may inform pathogenesis and provide new therapeutic targets. The PROCARDIS study recruited 2,658 affected sibling pairs (ASPs) with onset of CAD before age 66 y from four European countries to map susceptibility loci for CAD. ASPs were defined as having CAD phenotype if both ha...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Olsson, PG More by this author
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Journal:
PLoS genetics
Volume:
2
Issue:
5
Publication date:
2006-05-05
DOI:
EISSN:
1553-7404
URN:
uuid:9fea31d3-dd94-41d5-beed-3da6e869f691
Source identifiers:
91027
Local pid:
pubs:91027
Language:
English

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