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Working paper

Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation

Abstract:

Maintaining and limiting T cell responses to constant antigen stimulation is critical to eliminate pathogens and maintain self-tolerance, respectively. Antigen recognition by the T cell receptor (TCR) induces signalling that can activate T cells to produce cytokines and downregulation of the TCR. Precisely how TCR downregulation controls T cell responses to constant antigen stimulation is controversial. In other systems, receptor downregulation can induce perfect adaptation to constant stimul...

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Publication status:
Not Published
Peer review status:
Not peer reviewed
Version:
Author's Original

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Publisher copy:
10.1101/535385

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ORCID:
0000-0002-8078-5068
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0001-5847-5226
Publication date:
2019-01-30
DOI:
Pubs id:
pubs:968971
URN:
uri:9fe78434-cbf5-49bf-91e9-1529c9d7d3f4
UUID:
uuid:9fe78434-cbf5-49bf-91e9-1529c9d7d3f4
Local pid:
pubs:968971

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