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Journal article

IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

Abstract:

We present evidence that donor-reactive CD4(+) T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. CD4(+) T cells contained within the CD45RB(high) fraction remained capable of mediating graft rejection when transferred to donor alloantigen-grafted T cell-depleted mice. In contrast, the CD45RB(low) CD4(+) and CD25(+)CD4(+) populations failed to induce rejection, but rather, were able to inhibit rejection initiated by naive CD45RB(high) CD4...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.166.6.3789

Authors


Kingsley, CI More by this author
Turvey, SE More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
166
Issue:
6
Pages:
3789-3796
Publication date:
2001-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:9fe4a54b-58fb-4285-9f17-0200b0f40bed
Source identifiers:
10753
Local pid:
pubs:10753

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