Treatable Traits in Patients with Obstructive Lung Diseases in a Well-Established Asthma/COPD Service for Primary Care

Journal article

PurposeThe primary objective of this study was to assess the prevalence of treatable traits (TTs) in patients with obstructive lung diseases in a primary care setting and how these TTs co-occur. The secondary objective was to assess the stability of TTs and the effect of management advice on changes in traits and health outcomes.Patients and methodsData from the Dutch asthma/COPD service (2007-2023) were studied retrospectively. Patients ≥18 years with asthma, COPD, or Asthma-COPD overlap (ACO) were included. The prevalence of eight TTs were assessed: 1) insufficient inhaler technique, 2) poor medication adherence, 3) blood eosinophilia, 4) smoking, 5) obesity, 6) physical inactivity, 7) reversible airflow limitation, and 8) anxiety and/or depression. The effect of management advice on TTs was evaluated for patients with a follow-up visit scheduled within 1-2 years.ResultsIn total, 15246 patients (COPD n=4822; ACO n=1761, asthma n=8663) were included. The highest proportions of TTs were insufficient inhaler technique: 43.6% (95% CI: 42.9-44.4), followed by poor medication adherence: 40.3% (95% CI: 39.2-41.4) and blood eosinophilia: 36.9% (95% CI: 35.8-38.1). Overall, 83.3% of patients had ≥ 1 TTs, and 48.9% of patients ≥ 2 TTs. Among patients with blood eosinophilia, a significant reduction of the trait at follow-up (OR: 0.61, 95% CI: 0.39; 0.96) and improved health status were observed when the pulmonologist advised the general practitioner to initiate or increase the dose of ICS. No significant association was found between management advice and the exacerbation rate at follow-up.ConclusionThe TTs assessed in this study are common in primary care patients, with nearly half of the patients showing a combination of at least two TTs. These TTs coexist in many different combinations. A personalized approach targeting these traits may be effective in achieving better control of these heterogeneous diseases.

Authors: Dijk, L; Gerritsma, YH; Van der Molen, T; Pavord, I; Meijer, RJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Taylor and Francis Group
• Journal: International journal of chronic obstructive pulmonary disease
• Volume: 20
• Pages: 1189-1201
• Publication date: 2025-04-23
• Acceptance date: 2025-04-12
• DOI: 10.2147/copd.s508281
• EISSN: 1178-2005
• ISSN: 1176-9106
• Pmid: 40290584
• Language: English
• Keywords: Medication Adherence; Asthma-copd Overlap; Administration, Inhalation; COPD; Prevalence; Retrospective Studies; Female; Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome; Primary Health Care; Bronchodilator Agents; Treatable Traits; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Treatment Outcome; Adult; Aged; Time Factors; Risk Factors; Asthma; Precision Medicine; Netherlands; Male; Middle Aged