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Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Abstract:

MicroRNAs (miRNAs) have been shown to be key modulators of post-transcriptional gene silencing in many cellular processes. In previous studies designed to understand the role of miRNAs in thymic development, we globally deleted miRNA exclusively in thymic epithelial cells (TECs), which are critical in thymic selection. This resulted in the loss of stromal cells that instruct T cell lineage commitment and affect thymocyte positive selection, required for mature T cell development. Since murine...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0198871

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Role:
Author
ORCID:
0000-0001-7527-9315
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
6
Pages:
e0198871
Publication date:
2018-06-27
Acceptance date:
2018-05-25
DOI:
EISSN:
1932-6203
Pubs id:
pubs:859823
URN:
uri:9fd837f6-eabe-4dee-a0aa-74efb57fcab1
UUID:
uuid:9fd837f6-eabe-4dee-a0aa-74efb57fcab1
Local pid:
pubs:859823
Language:
English

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