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The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

Abstract:

The T cell Ag receptor (CD3/Ti) and the sheep E receptor (CD2) expressed on the surface of human T cells are both capable of initiating intracellular signals necessary for T cell activation. CD3/Ti interacts with Ag to initiate cellular immune responses. Although the exact function of CD2 is unknown, lymphocyte function-associated Ag 3 (LFA-3), a 55- to 70-kDa receptor expressed on a broad spectrum of hemopoietic and nonhemopoietic cells, has recently been shown to be its natural ligand. We s...

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
141
Issue:
6
Pages:
1904-1911
Publication date:
1988-09-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:9fd65610-b8bb-4ee8-83ee-5149e6a8c793
Source identifiers:
482711
Local pid:
pubs:482711

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