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Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes.

Abstract:

Productive beating of eukaryotic flagella and cilia requires a strict regulation of axonemal dynein activation. Fundamental to any description of axonemal beating is an understanding of the significance of the central pair microtubules and the degree to which central pair rotation has a role. However, for the majority of organisms, it is unclear whether the central pair actually rotates. Using an extra-axonemal structure as a fixed reference, we analysed the orientation of the central pair in...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.02969

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
119
Issue:
Pt 12
Pages:
2405-2413
Publication date:
2006-06-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:9fcc593b-0ed7-4e8e-96ff-59356ef3e187
Source identifiers:
19918
Local pid:
pubs:19918

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