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A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: domain swapping to introduce new activities.

Abstract:

Plant Family 1 glycosyltransferases (GTs) recognize a wide range of natural and non-natural scaffolds and have considerable potential as biocatalysts for the synthesis of small molecule glycosides. Regiospecificity of glycosylation is an important property, given that many acceptors have multiple potential glycosylation sites. This study has used a domain-swapping approach to explore the determinants of regiospecific glycosylation of two GTs of Arabidopsis thaliana, UGT74F1 and UGT74F2. The f...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m801983200

Authors


Cartwright, AM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Bowles, DJ More by this author
Journal:
The Journal of biological chemistry
Volume:
283
Issue:
23
Pages:
15724-15731
Publication date:
2008-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9fca5b39-1640-49e9-abd7-5241a2bb8b59
Source identifiers:
310202
Local pid:
pubs:310202

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